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Botulinum Toxin For Hair Loss
Blood vessels in the scalp travel through the intramuscular plane. An intramuscular injection of botulinum toxin relaxes these muscles and thereby assists in increased blood flow in balding scalps.
Botulinum toxin was found to be a safe and effective therapy for the management of androgic alopecia according to scientific studies.
Botulinum Toxin mechanism of action for hair loss
The proposed mechanism for hair growth in androgenic alopecia after botulinum toxin A treatment is that paralysis of the scalp muscles enhances blood flow to the scalp by reducing the tension on the scalp skin. Because the conversion to dihydrotestosterone (DHT) is enhanced in a low-oxygen environment, oxygenated blood reduces this conversion and increases conversion to estradiol. This might be the same mechanism by which minoxidil affects androgenic alopecia. The 18% increase in hair count is similar to that achieved with finasteride.
What do the studies show?
Hair counts increased 18% from baseline to 48 weeks after the initial injection of botulinum toxin type A. Hair loss was also significantly reduced, by 39%. The treatment response rate was 75%. The subjects noted statistically significant increased hair growth. No adverse events were noted.
Suggested treatment intervals
A total of three treatments done 24 weeks (six months) apart. Treatments to be administered for maintenance as needed.
Carboxy therapy for hair loss
Small volumes of the carbon dioxide gas are introduced into the epidermis of the scalp with a blushing technique (5-10° angle), only injecting the tip of the needle.
Carboxy therapy seems to be a promising therapeutic option for patchy alopecia areata and could be helpful as an adjuvant therapy of androgenic alopecia, but more than six sessions are required and adjuvants are recommended for maintenance of the results.
Patients with androgenic alopecia, when treated with carboxy therapy, showed significant clinical and dermoscopic improvement after carboxy therapy with significant increase in hair density measured by digital dermoscopy.
Patients with alopecia areata, when treated with carboxy therapy, presented with significant reduction in dystrophic hair, black dots, yellow dots, and tapered hair coinciding with significant emergence of regrowing hair.
Treatment recommendation
A series of treatments are required for best results. More frequent treatments will be necessary to establish clinical results with maintenance treatments following to maintain the results.
Initially one to two treatments are required weekly for the first 4-6 weeks. Followed by maintenance treatments of 1-2 sessions every 1-2 weeks, depending on the severity of the condition.
For patients participating in surgical hair transplants, it may be beneficial to perform carboxy therapy once a week, starting a week before the procedure and reinitiating a week after the hair transplant procedure to improve graft function and healing.
Carboxy therapy for hair loss
Small volumes of the carbon dioxide gas are introduced into the epidermis of the scalp with a blushing technique (5-10° angle), only injecting the tip of the needle.
Carboxy therapy seems to be a promising therapeutic option for patchy alopecia areata and could be helpful as an adjuvant therapy of androgenic alopecia, but more than six sessions are required and adjuvants are recommended for maintenance of the results.
Patients with androgenic alopecia, when treated with carboxy therapy, showed significant clinical and dermoscopic improvement after carboxy therapy with significant increase in hair density measured by digital dermoscopy.
Patients with alopecia areata, when treated with carboxy therapy, presented with significant reduction in dystrophic hair, black dots, yellow dots, and tapered hair coinciding with significant emergence of regrowing hair.
Treatment recommendation
A series of treatments are required for best results. More frequent treatments will be necessary to establish clinical results with maintenance treatments following to maintain the results.
Initially one to two treatments are required weekly for the first 4-6 weeks. Followed by maintenance treatments of 1-2 sessions every 1-2 weeks, depending on the severity of the condition.
For patients participating in surgical hair transplants, it may be beneficial to perform carboxy therapy once a week, starting a week before the procedure and reinitiating a week after the hair transplant procedure to improve graft function and healing.
Photodynamic Therapy For Hair Loss
Photodynamic therapy is a minimally invasive medical procedure that uses photo-active drugs called photo sensitisers, or light in isolation, to treat a range of diseases. With a two-step approach, a photo sensitiser is administered and, once it has permeated the target tissue, the photo sensitiser is then activated by exposure to a dose of electromagnetic (usually light) radiation at a particular wavelength, using the PDT machine.
PDT therapy showed a real efficacy in the field of hair loss, especially therapies involving the use of red and infrared wavelengths. Today, both laser and LED devices have FDA approval for hair loss. In two studies reported 655 nm red light significantly improved hair counts both in men and women with androgenic alopecia. A more recent study reported the effects of yellow LED device both on patients with androgenic alopecia and alopecia areata. The efficacy of LED therapy by visible light has also been recognised as a valid adjuvant therapy in the recalcitrant form of alopecia areata.
Treatment recommendation
Depends on PDT machine being used. Treatment duration at least 20 minutes long. Recommended frequency 1-3 times per week, depending on indication.
Photodynamic Therapy For Hair Loss
Photodynamic therapy is a minimally invasive medical procedure that uses photo-active drugs called photo sensitisers, or light in isolation, to treat a range of diseases. With a two-step approach, a photo sensitiser is administered and, once it has permeated the target tissue, the photo sensitiser is then activated by exposure to a dose of electromagnetic (usually light) radiation at a particular wavelength, using the PDT machine.
PDT therapy showed a real efficacy in the field of hair loss, especially therapies involving the use of red and infrared wavelengths. Today, both laser and LED devices have FDA approval for hair loss. In two studies reported 655 nm red light significantly improved hair counts both in men and women with androgenic alopecia. A more recent study reported the effects of yellow LED device both on patients with androgenic alopecia and alopecia areata. The efficacy of LED therapy by visible light has also been recognised as a valid adjuvant therapy in the recalcitrant form of alopecia areata.
Treatment recommendation
Depends on PDT machine being used. Treatment duration at least 20 minutes long. Recommended frequency 1-3 times per week, depending on indication.
Platelet rich plasma (prp) for hair loss
PRP is a volume of blood plasma which is concentrated ( >1 million platelets/μL ) with platelets. It is rich in growth factors contained in platelet alpha and dense granules.
These include:
- Platelet-derived growth factor (PDGF)
- Transforming growth factor beta (TGF-β)
- Epidermal growth factor (EGF)
- Vascular endothelial growth factor (VEGF)
These growth factors bind to their receptors at the bulb area of the hair follicle, in turn helping to activate the proliferative phase of hair growth. The use of PRP is recommended as a co-adjuvant treatment for androgenic alopecia as well as other types of alopecia where hair follicles are still present. Patients are encouraged to continue topical and/or oral therapies (such as minoxidil, spironolactone, and finasteride), as PRP does not suppress the hormonal component of androgenic alopecia.
Treatment recommendation
Treatment intervals should include monthly sessions for the first three months, then a fourth treatment six months later (for a total of four treatments over 12 months), followed by maintenance treatments every 12 to 18 months.
Platelet rich plasma (prp) for hair loss
PRP is a volume of blood plasma which is concentrated ( >1 million platelets/μL ) with platelets. It is rich in growth factors contained in platelet alpha and dense granules.
These include:
- Platelet-derived growth factor (PDGF)
- Transforming growth factor beta (TGF-β)
- Epidermal growth factor (EGF)
- Vascular endothelial growth factor (VEGF)
These growth factors bind to their receptors at the bulb area of the hair follicle, in turn helping to activate the proliferative phase of hair growth. The use of PRP is recommended as a co-adjuvant treatment for androgenic alopecia as well as other types of alopecia where hair follicles are still present. Patients are encouraged to continue topical and/or oral therapies (such as minoxidil, spironolactone, and finasteride), as PRP does not suppress the hormonal component of androgenic alopecia.
Treatment recommendation
Treatment intervals should include monthly sessions for the first three months, then a fourth treatment six months later (for a total of four treatments over 12 months), followed by maintenance treatments every 12 to 18 months.
Peptide Rich Mesotherapy
How do these peptides work?
Multiple scientific and clinical studies have shown that injectable peptides:
- Promotes increased blood circulation to the scalp and hair follicles
- Revitalises hair follicles and helps with hair stem cell proliferation
- Induces hair growth by increasing the size and number of hair follicles
- Prevents and reduces hair loss
- Maintains hair growth
By injecting this innovative sustained release complex of peptides into the dermis of the scalp, where the hair follicles are located, places the necessary active ingredients directly into the area of concern, thus increasing efficacy and end results.
Indications:
- Men and women suffering from alopecia (hair loss) from multiple causes, where the hair follicles are still present
- Men and women who have general hair thinning
- Patients with damaged hair from braiding, hair treatments, hair dyes etc.
- Hair transplant recipients who want to increase the transplant’s survival rate and maintain success
- For those wanting to encourage stronger healthier hair, as a preventative treatment to hair loss
